Modified triphosphates of carbocyclic nucleoside analogues: Synthesis, stability towards alkaline phosphatase and substrate properties for some DNA polymerases

被引：21

作者：

Dyatkina, N

Shirokova, E

Theil, F

Roberts, SM

Krayevsky, A

机构：

[1] VA ENGELHARDT MOL BIOL INST,MOSCOW 117984,RUSSIA

[2] CTR SELECT ORGAN SYNTH,D-12484 BERLIN,GERMANY

[3] UNIV LIVERPOOL,DEPT CHEM,LIVERPOOL L69 3BX,MERSEYSIDE,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 22期

基金：

俄罗斯基础研究基金会; 美国国家卫生研究院;

关键词：

D O I：

10.1016/S0960-894X(96)00482-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

New triphosphate derivatives of carbocyclic nucleoside analogues have been synthesized and shown to be potent substrates for terminal deoxynucleotidyltransferase and/or HIV reverse transcriptase; the compounds are stable to dephosphorylation with human placental alkaline phosphatase. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：2639 / 2642

页数：4

共 13 条

[1] ALPHA,BETA-METHYLENE AND BETA,GAMMA-METHYLENE 5'-PHOSPHONATE DERIVATIVES OF 3'-AZIDO-2',3'-DIDEOXYTHYMIDINE-5'-TRIPHOSPHATE - CORRELATION BETWEEN AFFINITY FOR REVERSE-TRANSCRIPTASE, SUSCEPTIBILITY TO HYDROLYSIS BY PHOSPHODIESTERASES AND ANTI-RETROVIRUS ACTIVITY [J].