STEREOCONTROLLED SYNTHESIS OF THE 4 STEREOISOMERIC DIPHOSPHORYLPHOSPHONATES OF CARBOCYCLIC 2',3'-DIDEOXY-2',3'-DIDEHYDRO-5'-NORADENOSINE

被引：30

作者：

DYATKINA, NB

THEIL, F

VONJANTALIPINSKI, M

机构：

[1] MAX DELBRUCK CTR MOLEC MED,D-13125 BERLIN,GERMANY

[2] VA ENGELHARDT MOLEC BIOL INST,MOSCOW 117984,RUSSIA

[3] INST ANGEW CHEM BERLIN ADLERSHOF,D-12484 BERLIN,GERMANY

来源：

TETRAHEDRON | 1995年 / 51卷 / 03期

关键词：

D O I：

10.1016/0040-4020(94)00986-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A flexible synthesis of the four stereoisomeric enantiomerically pure 5'-nor carbocyclic adenosine analogues 4b, ent-4b, 5b and ent-5b starting from the common enantio-merically pure allylic monoacetate 3 has been developed. Each of the nucleoside analogues was transformed into the corresponding 4'-phosphonates and subsequently into the diphosphoryl-phosphonates 4e, ent-4e, 5e, and ent-5e, respectively.

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页码：761 / 772

页数：12

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