Combing databases reveals potential antibiotic producers

被引：34

作者：

Kalia, Vipin Chandra ^{[1
]}

Rani, Asha ^{[1
]}

Lal, Sadhana ^{[1
]}

Cheema, Simrita ^{[1
]}

Raut, C. P. ^{[1
]}

机构：

[1] CSIR, Inst Genom & Integrat Biol, Delhi 110007, India

来源：

EXPERT OPINION ON DRUG DISCOVERY | 2007年 / 2卷 / 02期

关键词：

beta-lactam antibiotics; cephalosporin; conserved domains; data mining; penicillin;

D O I：

10.1517/17460441.2.2.211

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

The large-scale, persistent use of antibiotics has provoked microbes to evolve mechanisms to evade them. Pharmaceutical companies have found this to be counterproductive to their business economics. To maintain company interest to invest in this sector, innovative alternatives are needed. The availability of metabolic and genomic databases has opened up an avenue for such discoveries. Using these databases, potential producers of penicillin and cephalosporin have been traced. In addition, organisms that can be transformed from their present 'non'-producer status to antibacterial producers by supplementing their missing gene(s) by recombinant DNA technology have been revealed.

引用

页码：211 / 224

页数：14

共 63 条

[1]

Genetic improvement of processes yielding microbial products [J].

Adrio, JL ;

Demain, AL .

FEMS MICROBIOLOGY REVIEWS, 2006, 30 (02) :187-214

[2]

PENICILLIN AND CEPHALOSPORIN BIOSYNTHETIC GENES - STRUCTURE, ORGANIZATION, REGULATION, AND EVOLUTION [J].

AHARONOWITZ, Y ;

COHEN, G ;

MARTIN, JF .

ANNUAL REVIEW OF MICROBIOLOGY, 1992, 46 :461-495

[3]

Beyond comparison - antibiotics from genome data? [J].

Alekshun, MN .

NATURE BIOTECHNOLOGY, 2001, 19 (12) :1124-1125

[4]

New advances in antibiotic development and discovery [J].

Alekshun, MN .

EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2005, 14 (02) :117-134

[5]

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].

Altschul, SF ;

Madden, TL ;

Schaffer, AA ;

Zhang, JH ;

Zhang, Z ;

Miller, W ;

Lipman, DJ .

NUCLEIC ACIDS RESEARCH, 1997, 25 (17) :3389-3402

[6]

Automated genome sequence analysis and annotation [J].

Andrade, MA ;

Brown, NP ;

Leroy, C ;

Hoersch, S ;

de Daruvar, A ;

Reich, C ;

Franchini, A ;

Tamames, J ;

Valencia, A ;

Ouzounis, C ;

Sander, C .

BIOINFORMATICS, 1999, 15 (05) :391-412

[7]

β-Lactam synthetase:: A new biosynthetic enzyme [J].

Bachmann, BO ;

Li, RF ;

Townsend, CA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (16) :9082-9086

[8]

Genetic methods and strategies for secondary metabolite yield improvement in actinomycetes [J].

Baltz, RH .

ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY, 2001, 79 (3-4) :251-259

[9]

New genetic methods to improve secondary metabolite production in Streptomyces [J].

Baltz, RH .

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, 1998, 20 (06) :360-363

[10]

BARBER M, 2000, CEPHALOSPORINS BUSIN

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