Reduction of the anti-cancer drug analogue cis,trans,cis[PtCl2(OCOCH3)2(NH3)2] by L-cysteine and L-methionine and its crystal structure

被引：44

作者：

Chen, L ^{[1
]}

Lee, PF ^{[1
]}

Ranford, JD ^{[1
]}

Vittal, JJ ^{[1
]}

Wong, SY ^{[1
]}

机构：

[1] Natl Univ Singapore, Dept Chem, Singapore 119270, Singapore

来源：

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS | 1999年 / 08期

关键词：

D O I：

10.1039/a900441f

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The complex cis, tuans,cis-[PtCl2(OCOCH3)(2)(NH3)(2)] 1 has been synthesized as a simplified and more soluble mo del of the anticancer drug cis,trans,cis-[PtCl2(OCOCH3)(2)(NH3)(C6H11NH2)] (JM216). The crystal structure of 1 shows an octahedral co-ordination sphere around the Pt-IV with strong intramolecular and weak intermolecular hydrogen bonding. The kinetics of reduction of 1 by the divalent sulfur amino acids L-cysteine and L-methionine has been determined over a range of pH values by multinuclear NMR. The reduction is strongly pH dependent, being related to the protonation state of the amino acid and the basicity of the sulfur. Reduction rates an dramatically slower than for previous models of platinum(Iv) drug systems.

引用

页码：1209 / 1212

页数：4

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