Silencing viruses by RNA interference

被引：25

作者：

Colbère-Garapin, F ^{[1
]}

Blondel, B ^{[1
]}

Saulnier, A ^{[1
]}

Pelletier, I ^{[1
]}

Labadie, K ^{[1
]}

机构：

[1] Inst Pasteur, Lab Virus Enterotropes & Strategies Antivirales, F-75724 Paris, France

来源：

MICROBES AND INFECTION | 2005年 / 7卷 / 04期

关键词：

gene silencing; post-transcriptional gene silencing; RNA interference; RNAi siRNA; virus; review;

D O I：

10.1016/j.micinf.2005.02.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Post-transcriptional gene silencing (PTGS) makes possible new approaches for studying the various steps of the viral cycle. Plus-strand RNA viruses appear to be attractive targets for small interfering RNAs (siRNAs), as their genome functions as both mRNA and replication template. PTGS creates an alternative to classic reverse genetics for viruses with either negative-strand or double-stranded RNA genomes and for those with a large genome. PTGS allows modification of the expression of a given cellular gene as a means to elucidate its role in the viral cycle and in virus-host cell interactions, and to investigate cellular pathways involved in viral pathogenesis. It also allows the creation of new animal models of human diseases. In addition, PTGS already appears to be a promising new therapeutic tool to fight viral multiplication and dissemination through the host and to prevent inflammation and virus-induced pathogenesis, including virus-induced tumorigenesis. (c) 2005 Elsevier SAS. All rights reserved.

引用

页码：767 / 775

页数：9

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