Motor "Dexterity"?: Evidence that Left Hemisphere Lateralization of Motor Circuit Connectivity Is Associated with Better Motor Performance in Children

被引:49
作者
Barber, Anita D. [1 ,2 ]
Srinivasan, Priti [1 ]
Joel, Suresh E. [1 ,3 ]
Caffo, Brian S. [4 ]
Pekar, James J. [1 ,3 ]
Mostofsky, Stewart H. [1 ,2 ]
机构
[1] Kennedy Krieger Inst, Baltimore, MD 21205 USA
[2] Johns Hopkins Sch Med, Dept Neurol, Baltimore, MD 21205 USA
[3] Johns Hopkins Sch Med, Dept Radiol, Baltimore, MD 21205 USA
[4] Johns Hopkins Sch Publ Hlth, Dept Biostat, Baltimore, MD 21205 USA
基金
美国国家卫生研究院;
关键词
development; motor control; resting state network; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; BASAL GANGLIA; FUNCTIONAL CONNECTIVITY; RESPONSE-INHIBITION; HAND REPRESENTATION; CEREBELLAR OUTPUT; FINGER-MOVEMENTS; BRAIN ACTIVATION; HEALTHY-SUBJECTS; PREMOTOR CORTEX;
D O I
10.1093/cercor/bhr062
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Motor control relies on well-established motor circuits, which are critical for typical child development. Although many imaging studies have examined task activation during motor performance, none have examined the relationship between functional intrinsic connectivity and motor ability. The current study investigated the relationship between resting state functional connectivity within the motor network and motor performance assessment outside of the scanner in 40 typically developing right-handed children. Better motor performance correlated with greater left-lateralized (mean left hemisphere-mean right hemisphere) motor circuit connectivity. Speed, rhythmicity, and control of movements were associated with connectivity within different individual region pairs: faster speed was associated with more left-lateralized putamen-thalamus connectivity, less overflow with more left-lateralized supplementary motor-primary motor connectivity, and less dysrhythmia with more left-lateralized supplementary motor-anterior cerebellar connectivity. These findings suggest that for right-handed children, superior motor development depends on the establishment of left-hemisphere dominance in intrinsic motor network connectivity.
引用
收藏
页码:51 / 59
页数:9
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