Two new cytotoxic and virucidal trisulfated triterpene glycosides from the antarctic sea cucumber Staurocucumis liouvillei

被引：94

作者：

Maier, MS

Roccatagliata, AJ

Kuriss, A

Chludil, H

Seldes, AM

Pujol, CA

Damonte, EB

机构：

[1] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Quim Organ, RA-1428 Buenos Aires, DF, Argentina

[2] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Quim Biol, RA-1428 Buenos Aires, DF, Argentina

来源：

JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 06期

关键词：

D O I：

10.1021/np000584i

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new trisulfated triterpene glycosides, liouvillosides A (1) and B (2), have been isolated ft om the Antarctic sea cucumber Staurocucumis liouvillei. Their structures have been elucidated by spectroscopic analysis (NMR and FABMS) and chemical transformations. Liouvillosides A(1) and B (2) are two new examples of a small number of trisulfated triterpene glycosides from sea cucumbers belonging to the family Cucumariidae. Both glycosides were found to be virucidal against herpes simplex virus type 1 (HSV-1) at concentrations below 10 mug/mL.

引用

页码：732 / 736

页数：5

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