Effects of NSAIDs on IL-1 beta-induced IL-6 mRNA and protein synthesis in human astrocytoma cells

被引：38

作者：

Fiebich, BL ^{[1
]}

Lieb, K ^{[1
]}

Hull, M ^{[1
]}

Berger, M ^{[1
]}

Bauer, J ^{[1
]}

机构：

[1] UNIV FREIBURG,SCH MED,DEPT PSYCHIAT & PSYCHOTHERAPY,D-79104 FREIBURG,GERMANY

来源：

NEUROREPORT | 1996年 / 7卷 / 06期

关键词：

interleukin-6; interleukin-1; beta; non-steroidal anti-inflammatory drugs; tenidap; meloxicam; naproxen; astrocytes; neurodegeneration; Alzheimer's disease;

D O I：

10.1097/00001756-199604260-00023

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

INFLAMMATORY processes contribute to the aetiopathology of Alzheimer's disease (AD). Interleukin-6 (IL-6), a proinflammatory cytokine, is found in the brains of AD patients, but not in brains of normal control persons. In the present study, the effects of seven non-steroidal antiinflammatory drugs (NSAIDs) on interleukin-1 beta (IL-1 beta)-induced IL-6 mRNA expression and protein synthesis in a human astrocytoma cell line were investigated. Tenidap, naproxen and meloxicam inhibited the IL-1 beta-induced synthesis of IL-6, whereas ibuprofen, piroxicam, diclofenac and indomethacin had no effect. While the effects of naproxen and meloxicam were small and restricted to protein synthesis, tenidap strongly inhibited IL-6 protein synthesis and also affected IL-6 mRNA levels. It is concluded that NSAIDs, and particularly tenidap, may be useful for the treatment of inflammatory processes associated with AD.

引用

页码：1209 / 1213

页数：5

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