Syntheses and biological evaluation of new fluoroquinolone antibacterials containing chiral oxiimino pyrrolidine

被引：27

作者：

Choi, DR ^{[1
]}

Shin, JH ^{[1
]}

Yang, J ^{[1
]}

Yoon, SH ^{[1
]}

Jung, YH ^{[1
]}

机构：

[1] Dong Wha Pharm Ind Co Ltd, Cent Res Lab, Kyunggi 430017, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 05期

关键词：

antibacterial activity; fluoroquinolone; oxiimino pyrrolidine;

D O I：

10.1016/j.bmcl.2003.12.044

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The design and syntheses of new fluoroquinolone antibacterial agents having pyrrolidine ring at C-7 position are described. The pyrrolidine ring is optically active and possesses methyloxime functional group. Two of them have excellent in vitro antibacterial activities and pharmacokinetic profiles. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：1273 / 1277

页数：5

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