Metabolism of sphingosine 1-phosphate and lysophosphatidic acid:: a genome wide analysis of gene expression in Drosophila

被引：24

作者：

Renault, Andrew D. ^{[1
]}

Starz-Gaiano, Michelle ^{[1
]}

Lehmann, Ruth ^{[1
]}

机构：

[1] NYU, Ctr Med, Skirball Inst, Dev Genet Program, New York, NY 10016 USA

来源：

MECHANISMS OF DEVELOPMENT | 2002年 / 119卷

基金：

美国国家卫生研究院;

关键词：

Drosophila; lipid; sphingosine; phosphatidic acid; lysophosphatidic acid; 1-phosphate; ceramide; phospholipase A; diacylglycerol kinase; ceramidase; sphingomyelinase; lipid phosphate phosphohydrolase; wunen; 2; sphingosine kinase; sphingosine 1-phosphate lyase; fat body; nervous system; gut;

D O I：

10.1016/S0925-4773(03)00131-X

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Lipids, in addition to being structural components of cell membranes, can act as signaling molecules. Bioactive lipids, such as sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA), may act intracellularly as second messengers or be secreted and act as intercellular signaling molecules. Such molecules can affect a variety of cellular processes including apoptosis, proliferation, differentiation and motility. To investigate possible sources of bioactive lipids during development we have searched the Drosophila genome for homologs of genes involved in mammalian S1P and LPA metabolism. Here we report the developmental expression of 31 such genes by in situ hybridization to Drosophila embryos. Most show expression in specific tissues, with expression in the gut and nervous system being recurring patterns. (c) 2003 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：S293 / S301

页数：9

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