Metabolism of sphingosine 1-phosphate and lysophosphatidic acid:: a genome wide analysis of gene expression in Drosophila

被引：24

作者：

Renault, Andrew D. ^{[1
]}

Starz-Gaiano, Michelle ^{[1
]}

Lehmann, Ruth ^{[1
]}

机构：

[1] NYU, Ctr Med, Skirball Inst, Dev Genet Program, New York, NY 10016 USA

来源：

MECHANISMS OF DEVELOPMENT | 2002年 / 119卷

基金：

美国国家卫生研究院;

关键词：

Drosophila; lipid; sphingosine; phosphatidic acid; lysophosphatidic acid; 1-phosphate; ceramide; phospholipase A; diacylglycerol kinase; ceramidase; sphingomyelinase; lipid phosphate phosphohydrolase; wunen; 2; sphingosine kinase; sphingosine 1-phosphate lyase; fat body; nervous system; gut;

D O I：

10.1016/S0925-4773(03)00131-X

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Lipids, in addition to being structural components of cell membranes, can act as signaling molecules. Bioactive lipids, such as sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA), may act intracellularly as second messengers or be secreted and act as intercellular signaling molecules. Such molecules can affect a variety of cellular processes including apoptosis, proliferation, differentiation and motility. To investigate possible sources of bioactive lipids during development we have searched the Drosophila genome for homologs of genes involved in mammalian S1P and LPA metabolism. Here we report the developmental expression of 31 such genes by in situ hybridization to Drosophila embryos. Most show expression in specific tissues, with expression in the gut and nervous system being recurring patterns. (c) 2003 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：S293 / S301

页数：9

共 57 条

[11] SECRETORY PHOSPHOLIPASE A(2) GENERATES THE NOVEL LIPID MEDIATOR LYSOPHOSPHATIDIC ACID IN MEMBRANE MICROVESICLES SHED FROM ACTIVATED CELLS [J].

FOURCADE, O ;

SIMON, MF ;

VIODE, C ;

RUGANI, N ;

LEBALLE, F ;

RAGAB, A ;

FOURNIE, B ;

SARDA, L ;

CHAP, H .

CELL, 1995, 80 (06) :919-927

[12] Molecular analysis of a novel Drosophila diacylglycerol kinase, DGKε [J].

Frolov, MV ;

Benevolenskaya, EV ;

Birchler, JA .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2001, 1538 (2-3) :339-352

[13] Subcellular study of sphingoid base phosphorylation in rat tissues: evidence for multiple sphingosine kinases [J].

Gijsbers, S ;

Van der Hoeven, G ;

Van Veldhoven, PP .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2001, 1532 (1-2) :37-50

[14] Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1-phosphate [J].

Goetzl, EJ ;

An, SZ .

FASEB JOURNAL, 1998, 12 (15) :1589-1598

[15] A DROSOPHILA GENE ENCODING A PROTEIN WITH SIMILARITY TO DIACYLGLYCEROL KINASE IS EXPRESSED IN SPECIFIC NEURONS [J].

HARDEN, N ;

YAP, SF ;

CHIAM, MA ;

LIM, L .

BIOCHEMICAL JOURNAL, 1993, 289 :439-444

[16] A novel group of phospholipase A2s preferentially expressed in type 2 helper T cells [J].

Ho, IC ;

Arm, JP ;

Bingham, CO ;

Choi, A ;

Austen, KF ;

Glimcher, LH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (21) :18321-18326

[17]

Houssa B, 1997, J BIOL CHEM, V272, P10422

[18] Cloning and characterization of a glucocorticoid-induced diacylglycerol kinase [J].

Klauck, TM ;

Xu, XQ ;

Mousseau, B ;

Jaken, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (33) :19781-19788

[19] A gain-of-function screen for genes controlling motor axon guidance and synaptogenesis in Drosophila [J].

Kraut, R ;

Menon, K ;

Zinn, K .

CURRENT BIOLOGY, 2001, 11 (06) :417-430

[20] A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development [J].

Kupperman, E ;

An, SZ ;

Osborne, N ;

Waldron, S ;

Stainier, DYR .

NATURE, 2000, 406 (6792) :192-195

← 1 2 3 4 5 6 →