Fate of pharmaceuticals-photodegradation by simulated solar UV-light

被引：246

作者：

Doll, TE ^{[1
]}

Frimmel, FH ^{[1
]}

机构：

[1] Univ Karlsruhe, Engler Bunte Inst, D-76131 Karlsruhe, Germany

来源：

CHEMOSPHERE | 2003年 / 52卷 / 10期

关键词：

X-ray contrast media; lomeprol; carbamazepine; clofibric acid; natural organic matter; aquatic systems;

D O I：

10.1016/S0045-6535(03)00446-6

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The fate of pharmaceuticals in surface waters under solar irradiation was investigated. Photodegradation of pharmaceuticals caused by sun irradiation may be of major significance in the natural elimination process. Based on a data compilation from the literature, the lipid lowering agent metabolite clofibric acid, the iodinated X-ray contrast media iomeprol, which contribute to the adsorbable organic halogen compounds, and the antiepileptic drug carbamazepine were selected. The irradiation experiments were carried out in batch experiments with simulated UV-sunlight. The photodegradation of the pharmaceuticals showed a pseudo-first-order kinetics. The objective of this investigation was to demonstrate that the extent of photoinduced degradation of pharmaceuticals can vary significantly for the different pharmaceuticals and it strongly depends on the water constituents present in solution. The influences of different initial pharmaceutical concentrations, the presence of other pharmaceuticals like carbamazepine or clofibric acid and the presence of natural organic matter on the photochemical degradation rate of pharmaceuticals in aqueous solutions were investigated. Analyses of the pharmaceuticals and their photodegradation products were carried out by high performance liquid chromatography with diode-array and fluorescence detection. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：1757 / 1769

页数：13

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