Astragaloside IV suppresses transforming growth factor-β1-induced epithelial-mesenchymal transition through inhibition of Wnt/β-catenin pathway in glioma U251 cells

被引：35

作者：

Han, Jinming ^{[1
]}

Shen, Xiaohan ^{[2
]}

Zhang, Yong ^{[3
]}

Wang, Suying ^{[4
]}

Zhou, Leijie ^{[1
]}

机构：

[1] Ningbo 6 Hosp, Dept Spine Surg, Ningbo, Zhejiang, Peoples R China

[2] Lihuili Hosp, Ningbo Med Ctr, Ningbo Pathol Ctr, Ningbo Diagnost Pathol Ctr,Shanghai Canc Ctr, Ningbo, Zhejiang, Peoples R China

[3] Ningbo 6 Hosp, Dept Orthoped, Ningbo, Zhejiang, Peoples R China

[4] Ningbo Pathol Ctr, Shanghai Canc Ctr, Ningbo Diagnost Pathol Ctr, Ningbo, Zhejiang, Peoples R China

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2020年 / 84卷 / 07期

关键词：

Astragaloside; central nervous system tumors; epithelial-mesenchymal transition; glioma U251 cells; transforming growth factor-beta 1; SIGNALING PATHWAY; RESISTANCE; EXPRESSION; INVASION; TARGET;

D O I：

10.1080/09168451.2020.1737502

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Astragaloside IV (AS#IV) has previously demonstrated antitumoractivity. We investigated the effect and mechanisms of AS#IV in relation to epithelial-mesenchymal transition (EMT), viainterference with the Wnt/beta-catenin signaling pathway in gliomaU251 cells. Induction of glioma U251 cells by transforming growthfactor (TGF)#beta 1 activated EMT, including switching E#cadherin toN-cadherin and altering the expression of Wnt/beta-catenin signalingpathway components such as vimentin, beta-catenin, and cyclin-D1.AS-IV inhibited the viability, invasion, and migration of TGF-beta 1-induced glioma U251 cells. AS-IV also interfered with the TGF#beta 1-induced Wnt/beta-catenin signaling pathway in glioma U251 cells.These findings indicate that AS#IV prohibits TGF#beta 1-induced EMTby disrupting the Wnt/beta-catenin pathway in glioma U251 cells. AS#IV may thus be a potential candidate agent for treating glioma andother central nervous system tumors.

引用

页码：1345 / 1352

页数：8

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