Capture and release of protein by a reversible DNA-induced sol-gel transition system

被引：94

作者：

Wei, Bryan ^{[1
]}

Cheng, Immensee ^{[1
]}

Luo, Kathy Q. ^{[1
]}

Mi, Yongli ^{[1
]}

机构：

[1] Hong Kong Univ Sci & Technol, Dept Chem Engn, Kowloon, Hong Kong, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 02期

关键词：

Aptamers; Controlled release; DNA; Hydrogels; Sol-gel materials;

D O I：

10.1002/anie.200704143

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cross-links holding on, then letting go: Polyacrylamide main chains were branched with DNA strands, which could be gelatinized by DNA base pairing with a thrombin-bound cross-linking strand (see scheme). A complementary DNA strand can form a duplex with the cross-linking strand to dissolve the hydrogel and release the thrombin. (Chemical Equation Presented). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：331 / 333

页数：3

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