Amplified analysis of low-molecular-weight substrates or proteins by the self-assembly of DNAzyme-aptamer conjugates

被引:314
作者
Li Di [1 ]
Shlyahovsky, Bella [1 ]
Elbaz, Johann [1 ]
Willner, Itamar [1 ]
机构
[1] Hebrew Univ Jerusalem, Inst Chem, IL-91904 Jerusalem, Israel
关键词
D O I
10.1021/ja070180d
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Blocked aptamer-DNAzyme conjugates act as aptasensors for the amplified analysis of adenosine 5'-monophosphate or lysozyme.
引用
收藏
页码:5804 / +
页数:3
相关论文
共 17 条
[1]   Natural and engineered nucleic acids as tools to explore biology [J].
Breaker, RR .
NATURE, 2004, 432 (7019) :838-845
[2]   Automated selection of anti-protein aptamers [J].
Cox, JC ;
Ellington, AD .
BIOORGANIC & MEDICINAL CHEMISTRY, 2001, 9 (10) :2525-2531
[3]   Quantum-dot/aptamer-based ultrasensitive multi-analyte electrochemical biosensor [J].
Hansen, JA ;
Wang, J ;
Kawde, AN ;
Xiang, Y ;
Gothelf, KV ;
Collins, G .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (07) :2228-2229
[4]   Optical sensors based on hybrid aptamer/conjugated polymer complexes [J].
Ho, HA ;
Leclerc, M .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (05) :1384-1387
[5]   Aptamer-based sensor arrays for the detection and quantitation of proteins [J].
Kirby, R ;
Cho, EJ ;
Gehrke, B ;
Bayer, T ;
Park, YS ;
Neikirk, DP ;
McDevitt, JT ;
Ellington, AD .
ANALYTICAL CHEMISTRY, 2004, 76 (14) :4066-4075
[6]  
Klussmann S., 2006, APTAMER HDB FUNCTION
[7]   Fast colorimetric sensing of adenosine and cocaine based on a general sensor design involving aptamers and nanoparticles [J].
Liu, JW ;
Lu, Y .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (01) :90-94
[8]   Nucleic acid selection and the challenge of combinatorial chemistry [J].
Osborne, SE ;
Ellington, AD .
CHEMICAL REVIEWS, 1997, 97 (02) :349-370
[9]   Amplified chemiluminescence surface detection of DNA and telomerase activity using catalytic nucleic acid labels [J].
Pavlov, V ;
Xiao, Y ;
Gill, R ;
Dishon, A ;
Kotler, M ;
Willner, I .
ANALYTICAL CHEMISTRY, 2004, 76 (07) :2152-2156
[10]   Aptamer-functionalized Au nanoparticles for the amplified optical detection of thrombin [J].
Pavlov, V ;
Xiao, Y ;
Shlyahovsky, B ;
Willner, I .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (38) :11768-11769