A new device and protocol for combining TMS and online recordings of EEG and evoked potentials

被引:94
作者
Thut, G
Ives, JR
Kampmann, F
Pastor, MA
Pascual-Leone, A
机构
[1] Beth Israel Deaconess Med Ctr, Lab Magnet Brain Simulat, Boston, MA 02215 USA
[2] Beth Israel Deaconess Med Ctr, Dept Neurol, Neurophysiol Div, Boston, MA 02215 USA
[3] Univ Hosp Geneva, Dept Neurol, Funct Brain Mapping Lab, Geneva, Switzerland
[4] Univ Navarra, Sch Med, Dept Neurol, Clin Univ, Pamplona, Spain
[5] Inst Guttman, Barcelona, Spain
基金
美国国家卫生研究院;
关键词
electroencephalography; visual evoked potentials; steady-state auditory evoked potentials; Transcranial magnetic stimulation; neuroimaging; EEG-TMS combination;
D O I
10.1016/j.jneumeth.2004.06.016
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
We describe an electroencephalographic (EEG) device and protocol that allows recording of electrophysiological signals generated by the human brain during transcranial magnetic stimulation (TMS) despite the TMS-induced high-voltage artifacts. The key hardware components include slew-rate limited preamplifiers to prevent saturation of the EEG system due to TMS. The protocol involves artifact subtraction to isolate the electrophysiological signals from residual TMS-induced contaminations. The TMS compatibility of the protocol is illustrated with examples of two data sets demonstrating the feasibility of the approach in the single-pulse TMS design, as well as during repetitive TMS. Our data show that both high-amplitude potentials evoked by visual checkerboard stimulation and low-amplitude steady-state oscillations induced by auditory click-trains can be retrieved with the present protocol. The signals recorded during TMS perfectly matched control EEG responses to the same visual and auditory stimuli. The main field of application of the present protocol is in cognitive neuroscience complementing behavioral studies that use TMS to induce transient, 'virtual lesions'. Combined EEG-TMS techniques provide neuroscientists with a unique method to test hypothesis on functional connectivity, as well as on mechanisms of functional orchestration, reorganization, and plasticity. (C) 2004 Published by Elsevier B.V.
引用
收藏
页码:207 / 217
页数:11
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