Retinal stem cells: promising candidates for retina transplantation

被引：32

作者：

Djojosubroto, Meta W. ^{[1
]}

Arsenijevic, Yvan ^{[1
]}

机构：

[1] Univ Lausanne, Opthamol Dept, Jules Gonin Eye Hosp, Unit Gene Therapy & Stem Cell Biol, CH-1004 Lausanne, Switzerland

来源：

CELL AND TISSUE RESEARCH | 2008年 / 331卷 / 01期

关键词：

retina; stem cells; progenitor; differentiation; transplantation; radial glia;

D O I：

10.1007/s00441-007-0501-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Stem cell transplantation is widely considered as a promising therapeutic approach for photoreceptor degeneration, one of the major causes of blindness. In this review, we focus on the biology of retinal stem cells (RSCs) and progenitor cells (RPCs) isolated from fetal, postnatal, and adult animals, with emphasis on those from rodents and humans. We discuss the origin of RSCs/RPCs, the markers expressed by these cells and the conditions for the isolation, culture, and differentiation of these cells in vitro or in vivo by induction with exogenous stimulation.

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收藏

页码：347 / 357

页数：11

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