Emerging role of the apelin system in cardiovascular homeostasis

被引：9

作者：

Chong, Kwok S. ^{[1
]}

Gardner, Roy S. ^{[2
]}

Ashley, Euan A. ^{[3
]}

Dargie, Henry J. ^{[1
]}

McDonagh, Theresa A. ^{[4
]}

机构：

[1] Univ Glasgow, Western Infirm, Dept Cardiol, Glasgow G11 6NT, Lanark, Scotland

[2] Royal Infirm, Dept Cardiol, Glasgow G31 2ER, Lanark, Scotland

[3] Stanford Univ, Sch Med, Div Cardiovasc Med, Stanford, CA 94305 USA

[4] Royal Brompton Hosp, Dept Cardiol, London, England

来源：

BIOMARKERS IN MEDICINE | 2007年 / 1卷 / 01期

关键词：

D O I：

10.2217/17520363.1.1.37

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 [基础医学];

摘要：

The angiotensin receptor-like 1 (APJ) and its novel ligand, apelin, share similarities in structure and anatomical distribution with that of angiotensin II and the angiotensin II type 1 receptor. However, apelin has positive inotropic, vasodilatory and diuretic properties. Differential expression and synthesis of apelin and the APJ receptor in normal and failing hearts suggest that the apelin system may contribute to the pathophysiology of human heart failure and has potential therapeutic use in treatment of heart failure.

引用

页码：37 / 43

页数：7

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