Exhaled nitric oxide and bronchial reactivity during and after inhaled beclomethasone in mild asthma

被引：85

作者：

Silkoff, PE ^{[1
]}

McClean, PA ^{[1
]}

Slutsky, AS ^{[1
]}

Caramori, M ^{[1
]}

Chapman, KR ^{[1
]}

Gutierrez, C ^{[1
]}

Zamel, N ^{[1
]}

机构：

[1] Univ Toronto, Fac Med, Div Resp Med, Toronto, ON, Canada

来源：

JOURNAL OF ASTHMA | 1998年 / 35卷 / 06期

关键词：

exhaled; nitric oxide; asthma; bronchial reactivity;

D O I：

10.3109/02770909809071000

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The measurement of exhaled nitric oxide (ENO) is recognized as a marker of airway inflammation. ENO was measured in 10 nonsteroid-treated asthmatics at recruitment, during 3 weeks of inhaled beclomethasone (1000 mu g/day) and for 3 weeks after withdrawal. Baseline ENO was increased in asthma compared with nonasthmatics (85.0 +/- 54.5 vs. 24.5 +/- 14.8 ppb, p < 0.0001). After in haled steroid, there was no significant change in forced expiratory volume in 1 sec (FEV1) and forced vital capacity (FVC), but methacholine PC20 rose significantly (p = 0.0345). ENO (mean +/- SD; % baseline) fell after 1 week on steroid to 60.6 +/- 31.1 and rose to 95.3 +/- 46.1 at 1 week after withdrawal. ENO did not correlate with PC20 or FEV1. The changes in ENO and PC20 were inversely correlated (r(2) = 0.325). ENO may be an index of airway inflammation and therapeutic response in bronchial asthma.

引用

页码：473 / 479

页数：7

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