Loss of E-cadherin expression correlates with poor differentiation and invasion into a acent organs in gastric adenocarcinomas

被引:87
作者
Chen, HC
Chu, RY
Hsu, PN
Hsu, PI
Lu, JY
Lai, KH
Tseng, HH
Chou, NH
Huang, MS
Tseng, CJ
Hsiao, M
机构
[1] Kaohsiung Vet Gen Hosp, Dept Med Educ & Res, Kaohsiung 813, Taiwan
[2] Kaohsiung Vet Gen Hosp, Dept Internal Med, Kaohsiung 813, Taiwan
[3] Kaohsiung Vet Gen Hosp, Dept Pathol, Kaohsiung 813, Taiwan
[4] Kaohsiung Vet Gen Hosp, Dept Surg, Kaohsiung 813, Taiwan
[5] Kaohsiung Med Univ, Dept Internal Med, Kaohsiung, Taiwan
[6] Natl Taiwan Univ, Grad Inst Immunol, Taipei 10764, Taiwan
[7] Chang Gung Mem Hosp, Dept Radiat Oncol, Kaohsiung, Taiwan
关键词
gastric cancer; E-cadherin; differentiation; invasion; prognosis;
D O I
10.1016/j.canlet.2003.07.007
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Perturbation in E-cadherin expression leads to loss of cellular adhesion with possible consequence of cellular transformation and tumor progression. The aims of this study were to determine E-cadherin expression in each subtype of gastric cancer classified by different classification systems, and to investigate the role of E-cadherin in cell differentiation, cancer invasion and metastasis. Expression of E-cadherin was analyzed in 84 patients with gastric adenocarcinoma by immunohistochemistry and correlated with clinicopahotlogical parameters. Our results showed loss of E-cadherin expression in 0% (0/3), 20.0% (9/45), 48% (15/31), 100% (3/3) and 100% (2/2) of papillary, tubular, poorly differentiated, signet-ring cell, and mucinous adenocarcinoma by Japanese histological classification. The reduction of E-cadherin expression was inversely correlated with the grade of differentiation. According to the histological classification of Lauren and Ming, the frequency of lost E-cadherin expression was higher in diffuse type (65%) and infiltrative type (64%) gastric cancer than in intestinal type (20%, P < 0.001) and expanding type cancer (22%, P < 0.001), respectively. The loss of E-cadherin expression was significantly associated with tumor invasion (P < 0.05). Furthermore, there was a borderline association between the loss of E-cadherin expression and poor survival (P = 0.109). These data demonstrated a striking correlation between E-cadherin expression and the differentiation of gastric carcinoma. The loss of E-cadherin expression may contribute to gastric cancer invasion to adjacent organs. (C) 2003 Published by Elsevier Ireland Ltd.
引用
收藏
页码:97 / 106
页数:10
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