The Microbionne in Crohn's OCaossMazk Disease Role in Pathogenesis and Role of Microbiome Replacement Therapies

被引：53

作者：

Khanna, Sahil ^{[1
]}

Raffals, Laura E. ^{[1
]}

机构：

[1] Mayo Clin, Div Gastroenterol & Hepatol, 200 First St Southwest, Rochester, MN 55905 USA

来源：

GASTROENTEROLOGY CLINICS OF NORTH AMERICA | 2017年 / 46卷 / 03期

关键词：

Crohn's disease; Inflammatory bowel disease; Pathogenesis; Gut microbiota; Microbiome; Fecal microbiota transplantation; Probiotics; INFLAMMATORY-BOWEL-DISEASE; INTESTINAL BACTERIA; ESCHERICHIA-COLI; GUT MICROBIOME; TRANSPLANTATION; IMBALANCES; COMMENSALS; INDUCTION;

D O I：

10.1016/j.gtc.2017.05.004

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Individuals with a genetic predisposition to Crohn's disease develop aberrant immune responses to environmental triggers. The gastrointestinal microbiota is increasingly recognized to play an important role in the development of Crohn's disease. Decrease in global gut microbial diversity and specific bacterial alterations have been implicated in Crohn's disease. Advances in sequencing techniques and bioinformatics and correlation with host genetics continue to improve insight into the structure and function of the microbial community and interactions with the host immune system. This article summarizes the existing literature on the role of the gut microbiome and its manipulation in the development and management of Crohn's disease.

引用

页码：481 / +

页数：13

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