Epigenome programming by polycomb and trithorax proteins

被引：26

作者：

Cernilogar, FM ^{[1
]}

Orlando, V ^{[1
]}

机构：

[1] Dulbecco Telethon Inst, IGB, CNR, I-80131 Naples, Italy

来源：

BIOCHEMISTRY AND CELL BIOLOGY | 2005年 / 83卷 / 03期

关键词：

Polycomb; Trithorax; RNAi; cell memory; noncoding RNA; epigenome;

D O I：

10.1139/o05-040

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Polycomb group (PcG) and Trithorax group (TrxG) proteins work, respectively, to maintain repressed or active transcription states of developmentally regulated genes through cell division. Data accumulated in the recent years have increased our understanding of the mechanisms by which PcG and TrxG proteins regulate gene expression. The discovery that histone methylation can serve as a specific mark for PcG and TrxG complexes has provided new insight into the mechanistic function of this cell-memory system.

引用

页码：322 / 331

页数：10

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