Demystifying DNA Demethylation

被引：62

作者：

Nabel, Christopher S. ^{[1
]}

Kohli, Rahul M.

机构：

[1] Univ Penn, Perelman Sch Med, Dept Med, Philadelphia, PA 19104 USA

来源：

SCIENCE | 2011年 / 333卷 / 6047期

关键词：

5-METHYLCYTOSINE; GLYCOSYLASE; CONVERSION; GENOME; TET1;

D O I：

10.1126/science.1211917

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

引用

页码：1229 / 1230

页数：3

共 15 条

[1]

Specificity of human thymine DNA glycosylase depends on N-glycosidic bond stability [J].

Bennett, Matthew T. ;

Rodgers, M. T. ;

Hebert, Alexander S. ;

Ruslander, Lindsay E. ;

Eisele, Leslie ;

Drohat, Alexander C. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (38) :12510-12519

[2]

Reprogramming towards pluripotency requires AID-dependent DNA demethylation [J].

Bhutani, Nidhi ;

Brady, Jennifer J. ;

Damian, Mara ;

Sacco, Alessandra ;

Corbel, Stephane Y. ;

Blau, Helen M. .

NATURE, 2010, 463 (7284) :1042-U57

[3]

Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability [J].

Cortazar, Daniel ;

Kunz, Christophe ;

Selfridge, Jim ;

Lettieri, Teresa ;

Saito, Yusuke ;

MacDougall, Eilidh ;

Wirz, Annika ;

Schuermann, David ;

Jacobs, Angelika L. ;

Siegrist, Fredy ;

Steinacher, Roland ;

Jiricny, Josef ;

Bird, Adrian ;

Schaer, Primo .

NATURE, 2011, 470 (7334) :419-U210

[4]

Thymine DNA Glycosylase Is Essential for Active DNA Demethylation by Linked Deamination-Base Excision Repair [J].

Cortellino, Salvatore ;

Xu, Jinfei ;

Sannai, Mara ;

Moore, Robert ;

Caretti, Elena ;

Cigliano, Antonio ;

Le Coz, Madeleine ;

Devarajan, Karthik ;

Wessels, Andy ;

Soprano, Dianne ;

Abramowitz, Lara K. ;

Bartolomei, Marisa S. ;

Rambow, Florian ;

Bassi, Maria Rosaria ;

Bruno, Tiziana ;

Fanciulli, Maurizio ;

Renner, Catherine ;

Klein-Szanto, Andres J. ;

Matsumoto, Yoshihiro ;

Kobi, Dominique ;

Davidson, Irwin ;

Alberti, Christophe ;

Larue, Lionel ;

Bellacosa, Alfonso .

CELL, 2011, 146 (01) :67-79

[5]

Tissue Distribution of 5-Hydroxymethylcytosine and Search for Active Demethylation Intermediates [J].

Globisch, Daniel ;

Muenzel, Martin ;

Mueller, Markus ;

Michalakis, Stylianos ;

Wagner, Mirko ;

Koch, Susanne ;

Brueckl, Tobias ;

Biel, Martin ;

Carell, Thomas .

PLOS ONE, 2010, 5 (12)

[6]

Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain [J].

Guo, Junjie U. ;

Su, Yijing ;

Zhong, Chun ;

Ming, Guo-li ;

Song, Hongjun .

CELL, 2011, 145 (03) :423-434

[7]

Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA [J].

He, Yu-Fei ;

Li, Bin-Zhong ;

Li, Zheng ;

Liu, Peng ;

Wang, Yang ;

Tang, Qingyu ;

Ding, Jianping ;

Jia, Yingying ;

Chen, Zhangcheng ;

Li, Lin ;

Sun, Yan ;

Li, Xiuxue ;

Dai, Qing ;

Song, Chun-Xiao ;

Zhang, Kangling ;

He, Chuan ;

Xu, Guo-Liang .

SCIENCE, 2011, 333 (6047) :1303-1307

[8]

Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine [J].

Iqbal, Khursheed ;

Jin, Seung-Gi ;

Pfeifer, Gerd P. ;

Szabo, Piroska E. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (09) :3642-3647

[9]

Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine [J].

Ito, Shinsuke ;

Shen, Li ;

Dai, Qing ;

Wu, Susan C. ;

Collins, Leonard B. ;

Swenberg, James A. ;

He, Chuan ;

Zhang, Yi .

SCIENCE, 2011, 333 (6047) :1300-1303

[10]

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification [J].

Ito, Shinsuke ;

D'Alessio, Ana C. ;

Taranova, Olena V. ;

Hong, Kwonho ;

Sowers, Lawrence C. ;

Zhang, Yi .

NATURE, 2010, 466 (7310) :1129-U151

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