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Th1-and Th2-cell commitment during infectious disease: asymmetry in divergent pathways

被引：188
作者：
Jankovic, D
Liu, ZG
Gause, WC
机构：
[1] Uniformed Serv Univ Hlth Sci, Dept Microbiol & Immunol, Bethesda, MD 20814 USA
[2] NIAID, Immunobiol Sect, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA
来源：
TRENDS IN IMMUNOLOGY | 2001年 / 22卷 / 08期
关键词：
D O I：
10.1016/S1471-4906(01)01975-5
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The development of T helper 1 (Th1) versus Th2 cells is a major branch point in the immune response. It is an important determinant of whether the response to an infectious pathogen will lead to protection of the host or dissemination of the disease. Recent studies have suggested that this process is governed by distinct sets of signals provided by dendritic cells upon interactions with specific infectious agents. A model is proposed that links together the pathogen,the innate response and Th-cell polarization.
引用
收藏
页码：450 / 457
页数：10
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