Role of nuclear receptors for bile acid metabolism, bile secretion, cholestasis, and gallstone disease

被引：78

作者：

Claudel, Thierry ^{[2
]}

Zollner, Gernot ^{[2
]}

Wagner, Martin ^{[2
]}

Trauner, Michael ^{[1
]}

机构：

[1] Med Univ Vienna, Dept Internal Med 3, Div Gastroenterol & Hepatol, A-1090 Vienna, Austria

[2] Med Univ Graz, Dept Internal Med, Div Gastroenterol & Hepatol, Lab Expt & Mol Hepatol, Graz, Austria

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2011年 / 1812卷 / 08期

关键词：

Bile acids; Nuclear receptors; FXR; Cholestasis; Gallstone; Bile acid transport; FARNESOID-X-RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR; CHOLESTEROL 7-ALPHA-HYDROXYLASE GENE; VITAMIN-D-RECEPTOR; SALT EXPORT PUMP; NEGATIVE FEEDBACK-REGULATION; ACUTE-PHASE RESPONSE; HEPATOBILIARY TRANSPORTER EXPRESSION; RESISTANCE-ASSOCIATED PROTEIN-3; PRIMARY SCLEROSING CHOLANGITIS;

D O I：

10.1016/j.bbadis.2010.12.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Nuclear receptors (NRs) play a key role in the transcriptional control of critical steps of hepatobiliary transport and phase I/II metabolism of endo- and xenobiotics such as bile acids and drugs. Apart from these metabolic roles, NRs may also play a key role in the control of hepatic inflammation. Hereditary and acquired alterations of NRs contribute to our understanding of the pathogenesis of cholestasis and gallstone disease. Moreover, NRs may represent attractive drug targets for these disorders. This article is part of a Special Issue entitled: Translating nuclear receptors from health to disease. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：867 / 878

页数：12

共 278 条

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Chipping away at gallstones [J].