Novel water-soluble hexa(sulfobutyl)fullerenes as potent free radical scavengers

被引：60

作者：

Chi, Y

Bhonsle, JB

Canteenwala, T

Huang, JP

Shiea, J

Chen, BJ

Chiang, LY ^{[1
]}

机构：

[1] Natl Taiwan Univ, Ctr Condensed Matter Sci, Taipei 10764, Taiwan

[2] Natl Taiwan Univ, Dept Anim Sci, Taipei 10764, Taiwan

[3] Natl Sun Yat Sen Univ, Dept Chem, Kaohsiung 80424, Taiwan

来源：

CHEMISTRY LETTERS | 1998年 / 05期

关键词：

D O I：

10.1246/cl.1998.465

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel highly water-soluble hexa(sulfobutyl)fullerenes were synthesized via electron reductions of C-60. It showed an enhanced superoxide radical (O-2(-.)) Scavenging activity at a dose level of 100 mu M.

引用

页码：465 / 466

页数：2

共 11 条

[1] EVIDENCE OF HEMIKETALS INCORPORATED IN THE STRUCTURE OF FULLEROLS DERIVED FROM AQUEOUS ACID CHEMISTRY
CHIANG, LY
UPASANI, RB
SWIRCZEWSKI, JW
SOLED, S
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (13) : 5453 - 5457
[2] FREE-RADICAL SCAVENGING ACTIVITY OF WATER-SOLUBLE FULLERENOLS
CHIANG, LY
LU, FJ
LIN, JT
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1995, (12) : 1283 - 1284
[3] VERSATILE NITRONIUM CHEMISTRY FOR C-60 FULLERENE FUNCTIONALIZATION
CHIANG, LY
UPASANI, RB
SWIRCZEWSKI, JW
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (26) : 10154 - 10157
[4] INHIBITION OF THE HIV-1 PROTEASE BY FULLERENE DERIVATIVES - MODEL-BUILDING STUDIES AND EXPERIMENTAL-VERIFICATION
FRIEDMAN, SH
DECAMP, DL
SIJBESMA, RP
SRDANOV, G
WUDL, F
KENYON, GL
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (15) : 6506 - 6509
[5] DNA DAMAGE AND OXYGEN RADICAL TOXICITY
IMLAY, JA
LINN, S
[J]. SCIENCE, 1988, 240 (4857) : 1302 - 1309
[6] Water-soluble fullerene derivatives attenuate exsanguination-induced bronchoconstriction of guinea-pigs
Lai, YL
Chiang, LY
[J]. JOURNAL OF AUTONOMIC PHARMACOLOGY, 1997, 17 (04): : 229 - 235
[7] The reaction of [60]fullerene with lithium fluorenide: Formation of a novel 1,4-adduct of [60]fullerene
Murata, Y
Komatsu, K
Wan, TSM
[J]. TETRAHEDRON LETTERS, 1996, 37 (39) : 7061 - 7064
[8] Superoxide radical quenching and cytochrome c peroxidase-like activity of C-60-dimalonic acid, C-62(COOH)(4)
Okuda, K
Mashino, T
Hirobe, M
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (05) : 539 - 542
[9] PHOTOINDUCED BIOCHEMICAL-ACTIVITY OF FULLERENE CARBOXYLIC-ACID
TOKUYAMA, H
YAMAGO, S
NAKAMURA, E
SHIRAKI, T
SUGIURA, Y
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (17) : 7918 - 7919
[10] Polyhydroxylated C-60, fullerenol, a novel free-radical trapper, prevented hydrogen peroxide- and cumene hydroperoxide-elicited changes in rat hippocampus in-vitro
Tsai, MC
Chen, YH
Chiang, LY
[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1997, 49 (04) : 438 - 445

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