THE MECHANISM OF PROTRACTED WOUND HEALING ON ORAL MUCOSA IN DIABETES. REVIEW

被引：56

作者：

Abiko, Yoshihiro ^{[1
]}

Selimovic, Denis ^{[2
,3
]}

机构：

[1] Hlth Sci Univ Hokkaido, Dept Dent Sci, Div Oral Med & Pathol, Inst Personalized Med Sci,Kita Ku, Sapporo, Hokkaido 0028072, Japan

[2] Univ Hosp Strasbourg, Dept Oral Med & Surg, F-67000 Strasbourg, France

[3] INSERM, U977, F-67000 Strasbourg, France

来源：

BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES | 2010年 / 10卷 / 03期

关键词：

Diabetes; oral mucosa; wound healing; NERVE GROWTH-FACTOR; ADVANCED GLYCATION ENDPRODUCTS; PERIODONTAL-DISEASE; DIFFERENTIAL EXPRESSION; HUMAN KERATINOCYTES; SALIVARY SECRETION; OXIDATIVE STRESS; CUTANEOUS WOUNDS; FACTOR-BETA; IN-VITRO;

D O I：

10.17305/bjbms.2010.2683

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Diabetic patients increase their body's susceptibility to infection and diabetes is a risk factor for periodontal diseases and oral infection. Although many studies showed the mechanism of impaired wound healing in diabetes, there are still arguments to shed light on what kind of factors, including local and systemic factors are involved in the protracted wound healing. This review article summarizes reports on the wound healing in diabetes and discusses the mechanism of the protracted wound healing of the oral mucosa in diabetes. Delayed vascularization, reduction in blood flow, decline in innate immunity, decreases in growth factor production, and psychological stresses may be involved in the protracted wound healing of the oral mucosa in diabetics.

引用

页码：186 / 191

页数：6

共 85 条

[1]

Role of β-defensins in oral epithelial health and disease [J].

Abiko, Yoshihiro ;

Saitoh, Masto ;

Nishimura, Michiko ;

Yamazaki, Mami ;

Sawamura, Daisuke ;

Kaku, Tohru .

MEDICAL MOLECULAR MORPHOLOGY, 2007, 40 (04) :179-184

[2]

Salivary Defensins and their importance in oral health and disease [J].

Abiko, Yoshihiro ;

Saitoh, Masato .

CURRENT PHARMACEUTICAL DESIGN, 2007, 13 (30) :3065-3072

[3]

Salivary proteins: Protective and diagnostic value in cariology? [J].

Amerongen, AV ;

Bolscher, JGM ;

Veerman, ECI .

CARIES RESEARCH, 2004, 38 (03) :247-253

[4]

The role of endogenous nerve growth factor in human diabetic neuropathy [J].

Anand, P ;

Terenghi, G ;

Warner, G ;

Kopelman, P ;

WilliamsChestnut, RE ;

Sinicropi, DV .

NATURE MEDICINE, 1996, 2 (06) :703-707

[5]

Aydin S, 2007, J BIOCHEM MOL BIOL, V40, P29

[6]

Glucose and insulin are needed for optimal defensin expression in human cell lines [J].

Barnea, Maayan ;

Madar, Zecharia ;

Froy, Oren .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 367 (02) :452-456

[7]

Growth factors and cytokines in wound healing [J].

Barrientos, Stephan ;

Stojadinovic, Olivera ;

Golinko, Michael S. ;

Brem, Harold ;

Tomic-Canic, Marjana .

WOUND REPAIR AND REGENERATION, 2008, 16 (05) :585-601

[8]

Reduced expression of PDGF and PDGF receptors during impaired wound healing [J].

Beer, HD ;

Longaker, MT ;

Werner, S .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1997, 109 (02) :132-138

[9]

Bernardi Maria Jose, 2007, Oral Health Prev Dent, V5, P73

[10]

EFFECT OF GROWTH-FACTORS ON CELL-PROLIFERATION AND EPITHELIALIZATION IN HUMAN SKIN [J].

BHORA, FY ;

DUNKIN, BJ ;

BATZRI, S ;

ALY, HM ;

BASS, BL ;

SIDAWY, AN ;

HARMON, JW .

JOURNAL OF SURGICAL RESEARCH, 1995, 59 (02) :236-244

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