Mitochondrial regulation of apoptosis

被引：196

作者：

Mayer, B ^{[1
]}

Oberbauer, R ^{[1
]}

机构：

[1] Univ Vienna, Dept Nephrol, A-1090 Vienna, Austria

来源：

NEWS IN PHYSIOLOGICAL SCIENCES | 2003年 / 18卷

关键词：

D O I：

10.1152/nips.01433.2002

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Mitochondria play a central part in cellular survival and apoptotic death. These processes are highly regulated by pro- and antiapoptotic Bcl-2 superfamily members. A key feature within apoptosis cascades is disruption of mitochondrial transmembrane potential and apoptogenic protein release, caused by opening of the permeability transition pore (PT). New data, however, indicate that mitochondrial apoptosis may occur without PT involvement.

引用

页码：89 / 94

页数：6

共 14 条

[11] Discrete simulation of regulatory homo- and heterodimerization in the apoptosis effector phase [J].