Synthetic studies on concanamycin A: Total synthesis of concanolide A (concanamycin F)

被引:23
作者
Jyojima, T [1 ]
Miyamoto, N [1 ]
Katohno, M [1 ]
Nakata, M [1 ]
Matsumura, S [1 ]
Toshima, K [1 ]
机构
[1] Keio Univ, Fac Sci & Technol, Dept Appl Chem, Kohoku Ku, Yokohama, Kanagawa 2238522, Japan
关键词
concanolide A; concanamycin F; vacuolar H+-ATPase inhibitor; lactonization; Stille reaction; aldol reaction;
D O I
10.1016/S0040-4039(98)01234-9
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Enantioselective first total synthesis of concanolide A (concananycin F), which is one of a new class of macrolide antibiotics, concanamycins, has been achieved by a highly effective and convergent route. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:6007 / 6010
页数:4
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