Synthesis, physico-chemical properties and immunoadjuvant activity of water-soluble phosphazene polyacids

被引：20

作者：

Andrianov, AK ^{[1
]}

Sargent, JR ^{[1
]}

Sule, SS ^{[1
]}

Le Golvan, MP ^{[1
]}

Woods, AL ^{[1
]}

Jenkins, SA ^{[1
]}

Payne, LG ^{[1
]}

机构：

[1] Virus Res Inst Inc, Cambridge, MA 02138 USA

来源：

JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS | 1998年 / 13卷 / 04期

关键词：

D O I：

10.1177/088391159801300401

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Mixed-substituted polyphosphazenes containing carboxylic acid and alkyl ether side groups were synthesized and characterized. Physicochemical properties of phosphazene polyacids in aqueous solutions were investigated as a function of copolymer structure and composition. The immunoadjuvant activity of polyphosphazenes was evaluated by studying the effect of copolymers on the immunogenicity of the influenza virus in mice. Synthesized polyphosphazenes demonstrated the ability to enhance the immune response as compared to the levels elicited by the vaccine alone.

引用

页码：243 / 256

页数：14