IL-21 and IL-21 receptor - A new cytokine pathway modulates innate and adaptive immunity

被引：44

作者：

Collins, M ^{[1
]}

Whitters, MJ ^{[1
]}

Young, DA ^{[1
]}

机构：

[1] Wyeth Res, Immunol RA, Musculoskeletal Sci, Inflammat, Cambridge, MA 02140 USA

来源：

IMMUNOLOGIC RESEARCH | 2003年 / 28卷 / 02期

关键词：

IL-21; IL-21R; IL-21R-deficient mice; gamma-common; NK cell; T cell; B cell; cytokine;

D O I：

10.1385/IR:28:2:131

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin (IL)-21 is a new member of the type I cytokine superfamily. Although it is most homologous to IL-15, it has a unique receptor chain, IL-21R,that pairs with the gamma-common cytokine receptor chain. The first experiments examining the biology of the IL-21 pathway reveal that it is a cytokine with effects on natural killer (NK) cells, T cells, and B cells. Mice deficient in the IL-21R have also been made, and are being examined for the effects of the IL-21/IL-21R pathway in vivo. Here we summarize our current knowledge of this new cytokine pathway, and its role in innate and adaptive immunity.

引用

页码：131 / 140

页数：10

共 21 条

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