Synthesis and cyclodehydration of hydroxyphenols: A new stereoselective approach to 3-aryl-2,3-dihydrobenzofurans

被引：43

作者：

Bertolini, Ferruccio ^{[1
]}

Crotti, Paolo ^{[1
]}

Di Bussolo, Valeria ^{[1
]}

Macchia, Franco ^{[1
]}

Pineschi, Mauro ^{[1
]}

机构：

[1] Univ Pisa, Dipartimento Chim Bioorgan & Biofarm, I-56126 Pisa, Italy

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 72卷 / 20期

关键词：

D O I：

10.1021/jo070316q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A novel and simple method for the stereoselective synthesis of substituted 3-aryl-2,3-dihydrobenzofurans by intramolecular cyclization of hydroxyphenols is described. The stereoselective ortho-C-alkylation of phenols allows a novel and stereoselective access to a diverse array of polyfunctionalized products containing a diarylmethane stereogenic center without the need for time-consuming protection-deprotection steps.

引用

页码：7761 / 7764

页数：4

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