Lipophilicity coefficients of [11C]Me-Halo-CGS 27023A analogs determined by HPLC

被引：16

作者：

Fei, XS ^{[1
]}

Zheng, QH ^{[1
]}

机构：

[1] Indiana Univ, Sch Med, Dept Radiol, Indianapolis, IN 46202 USA

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES | 2005年 / 28卷 / 06期

基金：

美国国家卫生研究院;

关键词：

lipophilicity coefficients; C-11]Me-Halo-CGS 27023A; positron emission; tomography; tumor imaging agents; HPLC;

D O I：

10.1081/JLC-200051486

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

New radiolabeled matrix metalloproteinase inhibitors (MMPIs) [C-11]Me-Halo-CGS 27023A analogs have been synthesized for evaluation as potential novel positron emission tomography (PET) tumor imaging agents. Their lipophilicity coefficients (log P) were determined by C-18 reversed-phase HPLC method. These logP values were compared, and the correlations between lipophilicity and biological activity of selected analogs were made. The results suggest the appropriate level of lipophilic character in this class of compounds as useful imaging agents appears to be in the range of 2.00-2.67.

引用

页码：939 / 945

页数：7

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