V(D)J recombination - Ragtime jumping

被引：26

作者：

Plasterk, R ^{[1
]}

机构：

[1] Netherlands Canc Inst, Div Mol Biol, NL-1066 CX Amsterdam, Netherlands

来源：

NATURE | 1998年 / 394卷 / 6695期

关键词：

D O I：

10.1038/29389

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Transposons are stretches of DNA that contain all of the elements needed to ensure their own replication, and can hop about the genome at will. The RAG1 and RAG2 proteins, which were known to mediateV(D)Jrecombination, have now been shown to be capable of catalysing a full transposition reaction, and this has implications for the evolution of the immune system.

引用

页码：718 / 719

页数：2

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