Single crystals of aspirin form II: crystallisation and stability

被引：58

作者：

Bond, Andrew D. ^{[1
]}

Solanko, Katarzyna A. ^{[1
]}

Parsons, Simon ^{[2
,3
]}

Redder, Sascha ^{[4
]}

Boese, Roland ^{[4
]}

机构：

[1] Univ So Denmark, Dept Phys & Chem, DK-5230 Odense M, Denmark

[2] Univ Edinburgh, Sch Chem, Edinburgh EH9 3JJ, Midlothian, Scotland

[3] Univ Edinburgh, Ctr Sci Extreme Condit, Edinburgh EH9 3JJ, Midlothian, Scotland

[4] Univ Duisburg Essen, Inst Anorgan Chem, D-45117 Essen, Germany

来源：

CRYSTENGCOMM | 2011年 / 13卷 / 02期

关键词：

ACETYLSALICYLIC-ACID; POLYMORPHISM; DISSOLUTION; ANHYDRIDE; PRESSURE; DIFFRACTION; BEHAVIOR; ANVIL; CELL;

D O I：

10.1039/c0ce00588f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Single crystals of aspirin form II can be obtained by crystallisation of aspirin in the presence of aspirin anhydride in organic solvents such as acetonitrile or tetrahydrofuran. The crystals are stable under ambient conditions for months and do not show any phase transition on application of isotropic pressure up to 2.2 GPa.

引用

页码：399 / 401

页数：3

共 20 条

[1] Elastic Properties, Thermal Expansion, and Polymorphism of Acetylsalicylic Acid [J].

Bauer, Johannes D. ;

Haussuehl, Eiken ;

Winkler, Bjoern ;

Arbeck, Dirk ;

Milman, Victor ;

Robertson, Struan .

CRYSTAL GROWTH & DESIGN, 2010, 10 (07) :3132-3140

[2]

Bond A. D., 2007, AM PHARM REV MAY

[3]

Bond AD, 2007, ANGEW CHEM INT EDIT, V46, P618, DOI 10.1002/anie.200603373

[4] On the polymorphism of aspirin [J].

Bond, Andrew D. ;

Boese, Roland ;

Desiraju, Gautam R. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007, 46 (04) :615-617

[5] SPECTROPHOTOMETRIC DETERMINATION OF MICROGRAM QUANTITIES OF ACETYLSALICYLIC ANHYDRIDE IN ACETYLSALICYLIC ACID [J].

BUNDGAARD, H ;

BUNDGAARD, C .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1973, 25 (08) :593-598

[6] INFLUENCE OF AN ACETYLSALICYLIC ANHYDRIDE IMPURITY ON RATE OF DISSOLUTION OF ACETYLSALICYLIC-ACID [J].

BUNDGAARD, H .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1974, 26 (07) :535-540

[7] CRYSTAL-STRUCTURE AND SOLID-STATE BEHAVIOR OF ASPIRIN ANHYDRIDE CRYSTALS [J].

BYRN, SR ;

SIEW, PY .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1981, 70 (03) :280-283

[8] Use of a CCD diffractometer in crystal structure determinations at high pressure [J].

Dawson, A ;

Allan, DR ;

Parsons, S ;

Ruf, M .

JOURNAL OF APPLIED CRYSTALLOGRAPHY, 2004, 37 :410-416

[9]

Jerslev B., 1981, ARCH PHARM CHEMI SCI, V9, P61

[10]

KIM Y, 1985, CHEM PHARM BULL, V33, P2641

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