Endogenous interleukin-6 plays a crucial protective role in streptococcal toxic shock syndrome via suppression of tumor necrosis factor alpha production

被引：44

作者：

Diao, H

Kohanawa, M

机构：

[1] Hokkaido Univ, Inst Med Genet, Div Mol Immunol, Kita Ku, Sapporo, Hokkaido 0600815, Japan

[2] Hokkaido Univ, Dept Microbiol, Sch Med, Sapporo, Hokkaido 0600815, Japan

来源：

INFECTION AND IMMUNITY | 2005年 / 73卷 / 06期

关键词：

D O I：

10.1128/IAI.73.6.3745-3748.2005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During a Streptococcus pyogenes infection in interleukin-6 (IL-6)-deficient mice, there is elevation of serum tumor necrosis factor alpha (TNF-alpha) levels, muscular necrosis, and death compared with infection of C57BL/6 mice. Anti-TNF-alpha monoclonal antibody treatment decreased mortality and muscular necrosis in the infected IL-6-deficient mice. These results suggest that IL-6 plays a crucial protective role via suppression of TNF-a production in S. pyogenes infection.

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页码：3745 / 3748

页数：4

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