Endogenous interleukin-6 plays a crucial protective role in streptococcal toxic shock syndrome via suppression of tumor necrosis factor alpha production

被引：44

作者：

Diao, H

Kohanawa, M

机构：

[1] Hokkaido Univ, Inst Med Genet, Div Mol Immunol, Kita Ku, Sapporo, Hokkaido 0600815, Japan

[2] Hokkaido Univ, Dept Microbiol, Sch Med, Sapporo, Hokkaido 0600815, Japan

来源：

INFECTION AND IMMUNITY | 2005年 / 73卷 / 06期

关键词：

D O I：

10.1128/IAI.73.6.3745-3748.2005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During a Streptococcus pyogenes infection in interleukin-6 (IL-6)-deficient mice, there is elevation of serum tumor necrosis factor alpha (TNF-alpha) levels, muscular necrosis, and death compared with infection of C57BL/6 mice. Anti-TNF-alpha monoclonal antibody treatment decreased mortality and muscular necrosis in the infected IL-6-deficient mice. These results suggest that IL-6 plays a crucial protective role via suppression of TNF-a production in S. pyogenes infection.

引用

收藏

页码：3745 / 3748

页数：4

相关论文

共 18 条

[11] Epidemiology of invasive group A Streptococcus disease in the United States, 1995-1999 [J].

O'Brien, KL ;

Beall, B ;

Barrett, NL ;

Cieslak, PR ;

Reingold, A ;

Farley, MM ;

Danila, R ;

Zell, ER ;

Facklam, R ;

Schwartz, B ;

Schuchat, A .

CLINICAL INFECTIOUS DISEASES, 2002, 35 (03) :268-276

[12] Pathogenic role of interleukin-6 in the development of sepsis.: Part II:: Significance of anti-interleukin-6 and anti-soluble interleukin-6 receptor-α antibodies in a standardized murine contact burn model [J].

Pallua, N ;

Low, JFA ;

von Heimburg, D .

CRITICAL CARE MEDICINE, 2003, 31 (05) :1495-1501

[13] Lack of IL-6 augments inflammatory response but decreases vascular permeability in bacterial meningitis [J].

Paul, R ;

Koedel, U ;

Winkler, F ;

Kieseier, BC ;

Fontana, A ;

Kopf, M ;

Hartung, HP ;

Pfister, HW .

BRAIN, 2003, 126 :1873-1882

[14]

Schifrin BS, 2001, PRENAT NEONAT MED, V6, P75

[15] ASSOCIATION OF PHENOTYPIC AND GENOTYPIC CHARACTERISTICS OF INVASIVE STREPTOCOCCUS-PYOGENES ISOLATES WITH CLINICAL COMPONENTS OF STREPTOCOCCAL TOXIC SHOCK SYNDROME [J].

TALKINGTON, DF ;

SCHWARTZ, B ;

BLACK, CM ;

TODD, JK ;

ELLIOTT, J ;

BREIMAN, RF ;

FACKLAM, RR .

INFECTION AND IMMUNITY, 1993, 61 (08) :3369-3374

[16] Effect of anti-IL-6 and anti-10 monoclonal antibodies on the suppression of the normal T lymphocyte mitogenic response by steady state sickle cell disease sera [J].

Taylor, S ;

Shacks, S ;

Qu, Z .

IMMUNOLOGICAL INVESTIGATIONS, 2001, 30 (03) :209-219

[17] Growth hormone down-regulation of interleukin-1β and interleukin-6 induced acute phase protein gene expression is associated with increased gene expression of suppressor of cytokine signal-3 [J].

Wu, XW ;

Herndon, DN ;

Wolf, SE .

SHOCK, 2003, 19 (04) :314-320

[18] IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages [J].

Yasukawa, H ;

Ohishi, M ;

Mori, H ;

Murakami, M ;

Chinen, T ;

Aki, D ;

Hanada, T ;

Takeda, K ;

Akira, S ;

Hoshijima, M ;

Hirano, T ;

Chien, KR ;

Yoshimura, A .

NATURE IMMUNOLOGY, 2003, 4 (06) :551-556