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Molecular diagnostics by microelectronic microchips

被引：9
作者：
Ferrari, M
Cremonesi, L
Bonini, P
Stenirri, S
Foglieni, B
机构：
[1] Osped San Raffaele, IRCCS, Clin Mol Biol & Cytogenet Lab, Diagnost & Ric San Raffaele SPA, I-20132 Milan, Italy
[2] Osped San Raffaele, IRCCS, Unit Genomics Diag Human Pathol, I-20132 Milan, Italy
[3] Univ Vita Salute S Raffaele, Diagnost & Ric San Raffaele SPA, Dept Lab Med, I-20132 Milan, Italy
来源：
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS | 2005年 / 5卷 / 02期
关键词：
DNA; microchip; microelectronics; miniaturization; mutation detection; PCR; SNP;
D O I：
10.1586/14737159.5.2.183
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Molecular diagnostics Is being revolutionized by the development of highly advanced technologies for DNA and RNA testing. One of the most Important challenges Is the Integration of microelectronics to microchip-based nucleic acid technologies. The specific characteristics of these microsystems make the miniaturization and automation of any step of a molecular diagnostic procedure possible. This review describes the application of microelectronics to all the processes Involved In a genetic test, particularly to sample preparation, DNA amplification and sequence variation detection.
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页码：183 / 192
页数：10
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