Spirocycle assembly through selective tandem ring closing metathesis reactions

被引：89

作者：

Bassindale, MJ

Hamley, P

Leitner, A

Harrity, JPA

机构：

[1] Univ Sheffield, Dept Chem, Sheffield S3 7HF, S Yorkshire, England

[2] Astra Charnwood, Dept Med Chem, Loughborough LE11 5RH, Leics, England

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 16期

关键词：

D O I：

10.1016/S0040-4039(99)00375-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A range of functionalised spirocyclic systems have been prepared under mild and neutral conditions by tandem selective ring closing olefin metathesis reactions. Additionally, a marked preference for 5-membered ring closure over 7-membered ring closure was observed which appears to be a result of a kinetically favoured cyclisation process. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：3247 / 3250

页数：4

共 14 条

[11] Ruthenium-catalyzed ring closing olefin metathesis of non-natural alpha-amino acids [J].