Rh[III]-Catalyzed Direct C-H Amination Using N-Chloroamines at Room Temperature

被引：236

作者：

Grohmann, Christoph ^{[1
]}

Wang, Honggen ^{[1
]}

Glorius, Frank ^{[1
]}

机构：

[1] Univ Munster, Inst Organ Chem, D-48149 Munster, Germany

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 02期

基金：

欧洲研究理事会;

关键词：

CATALYZED DIRECT AMINATION; BOND FORMATION; OXIDATIVE OLEFINATION; ACID-DERIVATIVES; DIRECT ARYLATION; EFFICIENT; FUNCTIONALIZATION; ACTIVATION; REACTIVITY; AMIDATION;

D O I：

10.1021/ol203353a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient Rh(III)-catalyzed direct C-H amination of N-pivaloyloxy benzamides with N-chloroamines proceeding at room temperature was achieved. The versatile directing group allows for selective mono- and diamination and can be readily converted to give valuable benzamide or aminoaniline derivatives. Mechanistic studies have been carried out to elucidate the reaction pathway.

引用

页码：656 / 659

页数：4

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