Eukaryotic-type protein kinases in Streptomyces coelicolor:: variations on a common theme

被引：73

作者：

Petrícková, K ^{[1
]}

Petrícek, M ^{[1
]}

机构：

[1] ASCR, Inst Microbiol, Lab Physiol & Genet Actinomycetes, Prague 14220, Czech Republic

来源：

MICROBIOLOGY-SGM | 2003年 / 149卷

关键词：

D O I：

10.1099/mic.0.26275-0

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The increasing number of genes encoding eukaryotic-type Ser/Thr protein kinases (ESTPKs) in prokaryotes, identified mostly due to genome-sequencing projects, suggests that these enzymes play an indispensable role in many bacterial species. Some prokaryotes, such as Streptomyces coelicolor, carry numerous genes of this type. Though the regulatory pathways have been intensively studied in the organism, experimental proof of the physiological function of ESTPKs is scarce. This review presents a family portrait of the genes identified in the sequence of the S. coelicolor A3(2) genome. Based on the available experimental data on ESTPKs in streptomycetes and related bacteria, and on computer-assisted sequence analyses, possible roles of these enzymes in the regulation of cellular processes in streptomycetes are suggested.

引用

页码：1609 / 1621

页数：13

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