Binding mode of 6ECDCA, a potent bile acid agonist of the Farnesoid X Receptor (FXR)

被引：23

作者：

Costantino, G ^{[1
]}

Macchiarulo, A ^{[1
]}

Entrena-Guadix, A ^{[1
]}

Camaioni, E ^{[1
]}

Pellicciari, R ^{[1
]}

机构：

[1] Univ Perugia, Dipartimento Chim & Tecnol Farmaco, I-06123 Perugia, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 11期

关键词：

D O I：

10.1016/S0960-894X(03)00281-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Based on the folding conservation across the nuclear receptor superfamily and the sequence homology with RAR-gamma, we report the construction of a three dimensional model of the ligand binding domain of FXR. The model is exploited for the elucidation of the binding mode of 6alpha-ethyl-chenodeoxycholic acid. The results of the docking experiments give quite clear indications that the bile acid derivative would bind the receptor in a mode significantly different than that observed for agonists of other nuclear receptor superfamily. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：1865 / 1868

页数：4

共 25 条

[1]

*ACC, CER 2 INS 2

[2]

Claudel T, 2002, J CLIN INVEST, V109, P961

[3] The amino acid residues asparagine 354 and isoleucine 372 of human farnesoid X receptor confer the receptor with high sensitivity to chenodeoxycholate. [J].