Human leukocyte antigen and cytokine gene variants as predictors of recurrent Chlamydia trachomatis infection in high-risk adolescents

被引:40
作者
Wang, CB
Tang, JM
Geisler, WM
Crowley-Nowick, PA
Wilson, CM
Kaslow, RA
机构
[1] Univ Alabama Birmingham, Sch Med, Dept Med, Program Epidemiol Infect & Immun, Birmingham, AL 35294 USA
[2] Univ Alabama Birmingham, Sch Med, Dept Epidemiol, Program Epidemiol Infect & Immun, Birmingham, AL 35294 USA
[3] Univ Alabama Birmingham, Dept Pediat, Birmingham, AL 35294 USA
[4] Berlex Labs Inc, Dept Sci Affairs, Seattle, WA USA
关键词
D O I
10.1086/428592
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Antigen presentation and immune activation are essential to the effective control of infectious diseases. In 485 North American adolescents at high risk for genital Chlamydia trachomatis infection, we found 2 human leukocyte antigen variants ( DRB1* 03- DQB1* 04 and DQB1* 06) to be associated with recurrent Chlamydia infection ( adjusted relative odds [RO], >2.0 P < .01, for both variants). A G- C-C haplotype corresponding to variants at IL10 (encoding interleukin-10 [IL-10]) promoter positions - 1082, - 819, and - 592 was underrepresented in individuals with recurrent infection (RO, 0.59; P = .046). These genetic associations were independent of nongenetic factors, including number of sex partners, race, sex, duration of follow-up, and human immunodeficiency virus type 1 seropositivity. Consistent with the observed IL10 association, cervical secretions in female adolescents without the IL10 G- C-C haplotype had elevated IL-10 concentrations after Chlamydia infection, which may reflect involvement of a Chlamydia-specific mechanism for genetically mediated, differential IL-10 expression in the genital tract.
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收藏
页码:1084 / 1092
页数:9
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