Cyclebase.org - a comprehensive multi-organism online database of cell-cycle experiments

被引：51

作者：

Gauthier, Nicholas Paul ^{[1
]}

Larsen, Malene Erup ^{[1
]}

Wernersson, Rasmus ^{[1
]}

de Lichtenberg, Ulrik ^{[1
]}

Jensen, Lars Juhl ^{[2
]}

Brunak, Soren ^{[1
]}

Jensen, Thomas Skot ^{[1
]}

机构：

[1] Tech Univ Denmark, Biocentrum, Ctr Biol Sequence Anal, DK-2800 Lyngby, Denmark

[2] European Mol Biol Lab, D-69117 Heidelberg, Germany

来源：

NUCLEIC ACIDS RESEARCH | 2008年 / 36卷

关键词：

D O I：

10.1093/nar/gkm729

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The past decade has seen the publication of a large number of cell-cycle microarray studies and many more are in the pipeline. However, data from these experiments are not easy to access, combine and evaluate. We have developed a centralized database with an easy-to-use interface, Cyclebase.org, for viewing and downloading these data. The user interface facilitates searches for genes of interest as well as downloads of genome-wide results. Individual genes are displayed with graphs of expression profiles throughout the cell cycle from all available experiments. These expression profiles are normalized to a common timescale to enable inspection of the combined experimental evidence. Furthermore, state-of-the-art computational analyses provide key information on both individual experiments and combined datasets such as whether or not a gene is periodically expressed and, if so, the time of peak expression. Cyclebase is available at http://www.cyclebase.org.

引用

页码：D854 / D859

页数：6

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