Effect of supplementation with chromium picolinate on antibody titers to 5-hydroxymethyl uracil

被引：54

作者：

Kato, I ^{[1
]}

Vogelman, JH ^{[1
]}

Dilman, V ^{[1
]}

Karkoszka, J ^{[1
]}

Frenkel, K ^{[1
]}

Durr, NP ^{[1
]}

Orentreich, N ^{[1
]}

Toniolo, P ^{[1
]}

机构：

[1] NYU, Sch Med, Nelson Inst Environm Med, New York, NY 10010 USA

来源：

EUROPEAN JOURNAL OF EPIDEMIOLOGY | 1998年 / 14卷 / 06期

关键词：

autoantibodies; chromium picolinate; dietary supplement; DNA damage; HMdU;

D O I：

10.1023/A:1007442203258

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Recent in vitro studies have shown that chromium (III) compounds such as chromium picolinate, a popular dietary supplement among people trying to lose weight, produce chromosome damage. We monitored levels of DNA damage in a chromium picolinate supplement trial by measuring antibodies titers to an oxidized DNA base, 5-hydroxymethyl-2'-deoxyuridine (HMdU), by enzyme-linked immunosorbent assays. Ten obese volunteer women completed a 8-week course of 400 mu g chromium picolinate per day. In either absolute titers or percent of the baseline value, there were no changes in antibody titers at 4 or 8 weeks. The titers were very stable within individuals and those of one individual rarely crossed over others, which was reflected in an intraclass correlation coefficient of 0.99 (95% confidence interval: 0.96-1.00). There were no effects on glucose and lipid metabolism in this period. The results of this trial suggest that chromium (III) picolinate in a dose typically used for nutrient supplementation dose not increase oxidative DNA damage, as measured by anti-HMdU antibody levels.

引用

页码：621 / 626

页数：6

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