The haliclonacyclamines, cytotoxic tertiary alkaloids from the tropical marine sponge Haliclona sp.

被引：57

作者：

Clark, RJ

Field, KL

Charan, RD

Garson, MJ ^{[1
]}

Brereton, IM

Willis, AC

机构：

[1] Univ Queensland, Dept Chem, Brisbane, Qld 4072, Australia

[2] Univ Queensland, Ctr Magnet Resonance, Brisbane, Qld 4072, Australia

[3] Australian Natl Univ, Res Sch Chem, Canberra, ACT 0200, Australia

来源：

TETRAHEDRON | 1998年 / 54卷 / 30期

关键词：

alkaloids; NMR; piperidines; sponges;

D O I：

10.1016/S0040-4020(98)00473-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2D-NMR spectroscopic data is reported for the haliclonacyclamines A - D (1)-(4) and for two bismethiodide adducts (5) and (6). The structures of two new alkaloids, haliclonacyclamines C (3) and D (4), which are the 15,16-dihydro analogues of the haliclonacyclamines A (1) and B (2) are described. Revised assignments deduced by 2D-INADEQUATE spectroscopy are presented for (1) and (2). The alkene substituent in the C,, spacer group of (2) and (4) is positioned between C27-C28 by NMR, and confirmed by x-ray structural analysis for (2). Metabolite (3) has a C25-C26 double bond. (C) 1998 Elsevier Science Ltd. All rights reserved.

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收藏

页码：8811 / 8826

页数：16

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