Neural crest specification regulated by the helix-loop-helix repressor Id2

被引:126
作者
Martinsen, BJ
Bronner-Fraser, M [1 ]
机构
[1] CALTECH, Beckman Inst 139 74, Div Biol, Pasadena, CA 91125 USA
[2] Univ Calif Irvine, Dept Dev & Cell Biol, Irvine, CA 92717 USA
关键词
D O I
10.1126/science.281.5379.988
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Vertebrate neural crest cells, derived from the neural folds, generate a variety of tissues, such as cartilage, ganglia, and cranial.(intramembranous) bone, The chick homolog of the helix-loop-helix transcriptional regulator Id2 is expressed in cranial but not trunk neural folds and subsequently in some migrating cranial neural crest cells. Ectopic expression of Id2 with recombinant retroviruses converted ectodermal cells to a neural crest fate, demonstrating that proper regulation of Id2 is important for sustaining epidermal traits. In addition, overexpression of Id2 resulted in overgrowth and premature neurogenesis of the dorsal neural tube. These results suggest that Id2 may allocate ectodermal precursors into neural rather than epidermal lineages.
引用
收藏
页码:988 / 991
页数:4
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