Estrogen regulated proteases and antiproteases in ovarian and breast cancer cells

被引：37

作者：

Rochefort, H ^{[1
]}

Chalbos, D ^{[1
]}

Cunat, S ^{[1
]}

Lucas, A ^{[1
]}

Platet, N ^{[1
]}

Garcia, M ^{[1
]}

机构：

[1] Fac Med, INSERM, Unite 540, F-34090 Montpellier, France

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2001年 / 76卷 / 1-5期

关键词：

cathepsin D; estrogen; breast cancer;

D O I：

10.1016/S0960-0760(00)00142-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cathepsin D (cath-D), an estrogen-regulated protease appears mostly to increase the number of tumor cells rather than their invasion or motility through the extracellular matrix. Estradiol is mitogenic but in vitro it also inhibits invasion and motility. In this review, we discuss the mechanism of this inhibition and the hormonal regulation of other proteases and protease inhibitors possibly involved in the control of tumor cell invasion by estrogens. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：119 / 124

页数：6

共 51 条

[1] 17-BETA-ESTRADIOL REGULATES AND V-HA-RAS TRANSFECTION CONSTITUTIVELY ENHANCES MCF7 BREAST-CANCER CELL-INTERACTIONS WITH BASEMENT-MEMBRANE [J].

ALBINI, A ;

GRAF, J ;

KITTEN, GT ;

KLEINMAN, HK ;

MARTIN, GR ;

VEILLETTE, A ;

LIPPMAN, ME .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (21) :8182-8186

[2]

Ann F. C., 1997, J NATL CANCER I, V89, P1260

[3] FIBULIN IS AN EXTRACELLULAR-MATRIX AND PLASMA GLYCOPROTEIN WITH REPEATED DOMAIN-STRUCTURE [J].

ARGRAVES, WS ;

TRAN, H ;

BURGESS, WH ;

DICKERSON, K .

JOURNAL OF CELL BIOLOGY, 1990, 111 (06) :3155-3164

[4]

Beral V, 1997, LANCET, V350, P1047, DOI 10.1016/S0140-6736(97)08233-0

[5] The diagnostic and prognostic utility of prostate-specific antigen for diseases of the breast [J].

Black, MH ;

Diamandis, EP .

BREAST CANCER RESEARCH AND TREATMENT, 2000, 59 (01) :1-14

[6] Transcriptional control of matrix metalloproteinases and the tissue inhibitors of matrix metalloproteinases [J].

Borden, P ;

Heller, RA .

CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION, 1997, 7 (1-2) :159-178

[7] CATHEPSIN-D GENE IS CONTROLLED BY A MIXED PROMOTER, AND ESTROGENS STIMULATE ONLY TATA-DEPENDENT TRANSCRIPTION IN BREAST-CANCER CELLS [J].

CAVAILLES, V ;

AUGEREAU, P ;

ROCHEFORT, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (01) :203-207

[8] Estrogens increase the expression of fibulin-1, an extracellular matrix protein secreted by human ovarian cancer cells [J].

Clinton, GM ;

Rougeot, C ;

Derancourt, J ;

Roger, P ;

Defrenne, A ;

Godyna, S ;

Argraves, WS ;

Rochefort, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (01) :316-320

[9] ANTIESTROGEN ICI-164,384 REDUCES CELLULAR ESTROGEN-RECEPTOR CONTENT BY INCREASING ITS TURNOVER [J].

DAUVOIS, S ;

DANIELIAN, PS ;

WHITE, R ;

PARKER, MG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (09) :4037-4041

[10] Relationship between cathepsin-D content and disease free survival in node-negative breast cancer patients: A meta-analysis [J].

Ferrandina, G ;

Scambia, G ;

Bardelli, F ;

Panici, PB ;

Mancuso, S ;

Messori, A .

BRITISH JOURNAL OF CANCER, 1997, 76 (05) :661-666

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