Estrogen regulated proteases and antiproteases in ovarian and breast cancer cells

被引：37

作者：

Rochefort, H ^{[1
]}

Chalbos, D ^{[1
]}

Cunat, S ^{[1
]}

Lucas, A ^{[1
]}

Platet, N ^{[1
]}

Garcia, M ^{[1
]}

机构：

[1] Fac Med, INSERM, Unite 540, F-34090 Montpellier, France

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2001年 / 76卷 / 1-5期

关键词：

cathepsin D; estrogen; breast cancer;

D O I：

10.1016/S0960-0760(00)00142-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cathepsin D (cath-D), an estrogen-regulated protease appears mostly to increase the number of tumor cells rather than their invasion or motility through the extracellular matrix. Estradiol is mitogenic but in vitro it also inhibits invasion and motility. In this review, we discuss the mechanism of this inhibition and the hormonal regulation of other proteases and protease inhibitors possibly involved in the control of tumor cell invasion by estrogens. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：119 / 124

页数：6

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