Minireview: Mitochondrial energetics and insulin resistance

被引：56

作者：

Civitarese, Anthony E. ^{[1
]}

Ravussin, Eric ^{[1
]}

机构：

[1] Pennington Biomed Res Ctr, Skeletal Muscle Metab Lab, Baton Rouge, LA 70808 USA

来源：

ENDOCRINOLOGY | 2008年 / 149卷 / 03期

关键词：

D O I：

10.1210/en.2007-1444

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Obesity, insulin resistance, type 2 diabetes mellitus, and aging are associated with impaired skeletal muscle oxidation capacity, reduced mitochondrial content, and lower rates of oxidative phosphorylation. Several studies have reported ultrastructural abnormalities in mitochondrial morphology and reductions in mitochondrial mass in insulin-resistant individuals. From lower organisms to rodents, mitochondrial membrane structure, function, and programmed cell death are regulated in part by the balance between the opposing forces of mitochondrial fusion and fission, suggesting they may also play an important role in human physiology.

引用

页码：950 / 954

页数：5

共 57 条

[1] Ceramide content is increased in skeletal muscle from obese insulin-resistant humans [J].

Adams, JM ;

Pratipanawatr, T ;

Berria, R ;

Wang, E ;

DeFronzo, RA ;

Sullards, MC ;

Mandarino, LJ .

DIABETES, 2004, 53 (01) :25-31

[2] Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism -: A novel regulatory mechanism altered in obesity [J].

Bach, D ;

Pich, S ;

Soriano, FX ;

Vega, N ;

Baumgartner, B ;

Oriola, J ;

Daugaard, JR ;

Lloberas, J ;

Camps, M ;

Zierath, JR ;

Rabasa-Lhoret, R ;

Wallberg-Henriksson, H ;

Laville, M ;

Palacín, M ;

Vidal, H ;

Rivera, F ;

Brand, M ;

Zorzano, A .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (19) :17190-17197

[3] Impaired mitochondrial substrate oxidation in muscle of insulin-resistant offspring of type 2 diabetic patients [J].

Befroy, Douglas E. ;

Petersen, Kitt Falk ;

Dufour, Sylvie ;

Mason, Graeme F. ;

de Graaf, Robin A. ;

Rothman, Douglas L. ;

Shulman, Gerald I. .

DIABETES, 2007, 56 (05) :1376-1381

[4]

Bjorntorp P, 1967, Diabetologia, V3, P346, DOI 10.1007/BF00429867

[5] Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2Cl2 myotubes [J].

Chavez, JA ;

Summers, SA .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2003, 419 (02) :101-109

[6] OPA1 requires mitofusin 1 to promote mitochondrial fusion [J].

Cipolat, S ;

de Brito, OM ;

Dal Zilio, B ;

Scorrano, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (45) :15927-15932

[7] Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling [J].

Cipolat, Sara ;

Rudka, Tomasz ;

Hartmann, Dieter ;

Costa, Veronica ;

Serneels, Lutgarde ;

Craessaerts, Katleen ;

Metzger, Kristine ;

Frezza, Christian ;

Annaert, Wim ;

D'Adamio, Luciano ;

Derks, Carmen ;

Dejaegere, Tim ;

Pellegrini, Luca ;

D'Hooge, Rudi ;

Scorrano, Luca ;

De Strooper, Bart .

CELL, 2006, 126 (01) :163-175

[8] Role of adiponectin in human skeletal muscle bioenergetics [J].

Civitarese, Anthony E. ;

Ukropcova, Barbara ;

Carling, Stacy ;

Hulver, Matthew ;

DeFronzo, Ralph A. ;

Mandarino, Lawrence ;

Ravussin, Eric ;

Smith, Steve R. .

CELL METABOLISM, 2006, 4 (01) :75-87

[9] Mitochondrial function, fibre types and ageing:: new insights from human muscle in vivo [J].

Conley, Kevin E. ;

Amara, Catherine E. ;

Jubrias, Sharon A. ;

Marcinek, David J. .

EXPERIMENTAL PHYSIOLOGY, 2007, 92 (02) :333-339

[10] Mitochondrial morphology and distribution in mammalian cells [J].

Frazier, Ann E. ;

Kiu, Clement ;

Stojanovski, Diana ;

Hoogenraad, Nicholas J. ;

Ryan, Michael T. .

BIOLOGICAL CHEMISTRY, 2006, 387 (12) :1551-1558

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